|
KMID : 0363320170380030367
|
|
Journal of Korean Oriental Internal Medicine
2017 Volume.38 No. 3 p.367 ~ p.375
|
|
|
The Effects of Artemisiae Iwayomogii Herba, Curcumae Radix, and Aurantii Fructus Immaturus Complex Extract (ACA) on Dyslipidemia-related Factor Expression and Anti-oxidation in HepG2 Cells
|
|
Ryu Ju-Young
Cho Hyun-Kyoung
Yoo Ho-Rhyong
Seol In-Chan
Kim Yoon-Sik
|
|
|
Abstract
|
|
|
Objectives: To ianvestigate the effect of Artemisiae Iwayomogii Herba, Curcumae Radix, and Aurantii Fructus Immaturus complex extract (ACA) on dyslipidemia-related factor expression and anti-oxidation in HepG2 cells.
Method: After treatment with ACA in the HepG2 cells, DPPH, ABTS radical scavenging activity, ROS production, and glutathione (GSH) production were measured. The free fatty acid, lipid peroxidation (MDA), ACAT1, and HMG-CoA reductase mRNA expression were measured in the HepG2 cells after treatment with ACA.
Results: 1.DPPH, ABTS radical scavenging activity increased in an ACA concentration-dependent manner.
2.ACA significantly decreased ROS production in comparison to the control group.
3. ACA significantly increased glutathione production.
4.ACA significantly decreased free fatty acid and lipid peroxidation (MDA) in the HepG2 cells.
5.ACA decreased the mRNA expression of ACAT1 and HMG-CoA reductase.
Conclusion: These results suggest that Artemisiae Iwayomogii Herba, Curcumae Radix, and Aurantii Fructus Immaturus complex extract (ACA) inhibits dyslipidemia-related factor expression and that it is effective in anti-oxidation. A future in vivo experiment with ACA is needed to investigate the effect on anti-dyslipidemia. It is expected that ACA is effective in anti-dyslipidemia and applied to cardiovascular disease, ischemic heart disease, stroke, etc.
|
|
|
KEYWORD
|
|
|
Artemisiae Iwayomogii Herba, Curcumae Radix, Aurantii Fructus Immaturus, anti-oxidation, dyslipidemia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|